CPIRO Calculator Fields marked with an * are required CPIRO Calculator In order to calculate the CPIRO Score for your patient and determine the eligibility for the COOL study please answer all of the questions below. Once the score has been determined and is displayed, enter the score where requested. A click here box will then appear that will re-direct you to randomize the patient or not. Divider Predisposition Does your patient have any of the following predispositions? Age > 65 years * No Yes Comorbidities * The following defines “chronic organ insufficiency” and immunocompromise:Liver insufficiencyBiopsy proven cirrhosisDocumented portal hypertensionEpisodes of past upper GI bleeding attributed to portal hypertensionPrior episodes of hepatic failure / encephalopathy / comaCardiovascularNew York Heart Association Class IV Heart Failure: Unable to carry on any physical activity without discomfort, Symptoms of heart failure at rest. If any physical activity is undertaken, discomfort increases.RespiratoryChronic restrictive, obstructive or vascular disease resulting in severe exercice restriction, i.e. unable to climb stairs or perform household dutiesDocumented chronic hypoxia, hypercapnia, secondary polycythemia , severe pulmonary hypertension (> 40 mmHg), or respirator dependencyRenalReceiving chronic dialysisImmunosuppressionThe patient has received therapy that suppresses resistance to infection e.g. immuno-suppression, chemotherapy, radiation, long term or recent hight dose steroids, or has a disease that is sufficiently advanced to suppress resistance to infection, e.g. leukemia, lymphoma, AIDS No Yes Click the for the definition of comorbidities Divider Response Did your patient have any of the following responses? Leukopenia * Leukopenia is defined as WBC <4000 No Yes Leukopenia is defined as WBC <4000 Hypothermia * Hypothermia is defined as a temperature less than 36 degrees Celsius No Yes Hypothermia is defined as a temperature less than 36 degrees Celsius Divider Organ Dysfunction Does your patient have any of the following organ dysfunction? Cardiovascular dysfunction * Mean arterial pressure < 90 OR administration of any vasopressor medications No Yes Mean arterial pressure < 90 OR administration of any vasopressor medications Respiratory Dysfunction * PaO2/FiO2 (mmHg) <300 No Yes PaO2/FiO2 (mmHg) <300 Renal Dysfunction * Creatinine > 171 umol/L (2 mg/dl) OR < 500 ml urine day No Yes Creatinine > 171 umol/L (2 mg/dl) OR < 500 ml urine day CNS Dysfunction * Glasgow Coma Scale ≤ 12 No Yes Glasgow Coma Scale ≤ 12 Divider Final CPIRO Score Total CPIRO Score: 0 Divider If you are a human seeing this field, please leave it empty.